THE RELATIONSHIP BETWEEN PHYSICAL-CHEMICAL CHARACTERISTICS AND BIOLOGICAL ACTIVITY OF PEPTIDE 562—572 OF LUTEINIZING HORMONE RECEPTOR MODIFIED BY DECANOYL RADICALS AT THE N- AND C-TERMINI.

Lipophilic derivatives of peptides corresponding to the cytoplasmic regions associated with the G-protein coupled receptors (GPCRs) are capable of functioning as an intracellular agonist. Previously, we have shown that peptides corresponding to region 562—572 of luteinizing hormone receptor (LHR) and modified by decanoate and palmitate at the C-terminus activate adenylyl cyclase (AC) in the testes of rats. The stimulating effect of peptide 562—572 modified by decanoates at the N- and C-termini (IV) peaked at a concentration of 10(–5) M and then subsequently decreased with increasing concentration.