[Efficacy and safety of bisoprolol in pregnant women with chronic arterial hypertension do not depend on genetic CYP2D6 polymorphism].

The investigation has been conducted with the aim of studying association between polymorphic marker G1846A of CYP2D6 gene and efficacy and safety of bisoprolol in 64 pregnant women with chronic stage I and II hypertension. These women have been under observation during trimesters II and III of pregnancy. Results of the study evidence for the absence of differences in frequencies of alleles and genotypes of polymorphic marker CYP2D6 of CYP2D6 gene between groups with various regimens of antihypertensive therapy.

[Effect of a short course of beta-blocker treatment on the central hemodynamics and work capacity of patients with neurocirculatory dystonia].

Changes in central hemodynamics, systolic phase structure and capacity for physical work were examined, using respiration ergometry, in patients with neurocirculatory dystonia after a short course of treatment with beta-blockers. It was demonstrated that the treatment resulted in the eukinetic type of circulation, yet changes in physical working capacity showed opposite tendencies: oxygen support of exercise was improved in some patients only. A short-term beta-blocker treatment course can be used as a test of adequacy of the chosen therapy.

[The oxygen supply in patients with neurocirculatory asthenia during exercise].

The working capacity and the oxygen supply during exercise were studied in 83 patients with neurocirculatory dystonia of various severity and 50 healthy subjects on the basis of the spiroergometric findings. The patients with neurocirculatory dystonia showed a decrease in such parameters of the oxygen supply during "maximum" exercise as the maximum consumption of oxygen at the threshold exercise level, the maximum oxygen pulse, the maximum pulmonary ventilation and the index of the oxygen cost per 1 kgm of work. The correlation of the disorders of the oxygen supply during exercise with the severity of the clinical course of the disease elucidated their relationship: a decrease in the maximum oxygen consumption at the threshold exercise level and an increase in the "oxygen cost" of 1 kgm of work were most pronounced in a group of patients with a severe course of the disease.