Pediatric chordoma associated with tuberous sclerosis complex: A rare case report with a thorough analysis of potential therapeutic molecular targets.

Chordoma associated with tuberous sclerosis complex (TSC) is an extremely rare tumor that was described only in 13 cases since 1975. Сhordoma itself is a malignant slow-growing bone tumor thought to arise from vestigial or ectopic notochordal tissue. Chordoma associated with TSC differs from chordoma in the general pediatric population in the median age, where the diagnosis of TSC-associated chordoma is 6.

[Occupational bronchial asthma due to organic solvents].

Thorough clinical, allergologic and immunologic examination of 65 patients who worked as building painters in contact with organic solvents proved these agents, not being allergens, to contribute in formation of occupational bronchial asthma. This type of bronchial asthma is characterized by some clinical features and pathogenetic mechanisms. A complex of clinical, allergologic and immunologic methods was elaborated to diagnose this type of bronchial asthma.

[A biochemical assessment of the glucocorticoid function of the adrenal cortex in patients with occupational bronchial asthma and asthmatic bronchitis].

The article contains a study of the basal level and the circadian rhythm of the hydrocortisone secretion in patients with occupational bronchial asthma and asthmatic bronchitis. Relationships were established between the hydrocortisone secretion levels and severity of the clinical course. Circadian rythm disorders resulted into double hydrocortisone secretion increases at 8 a.