Publications by authors named "E A Schumann"
Objective: Cerebrospinal fluid (CSF) provides unique insights into the brain and neurological diseases. However, the potential of CSF flow cytometry applied on a large scale remains unknown.
Methods: We used data-driven approaches to analyze paired CSF and blood flow cytometry measurements from 8,790 patients (discovery cohort) and CSF only data from 3,201 patients (validation cohort) collected across neurological diseases in a real-world setting.
Progressive multifocal leukoencephalopathy (PML) has been associated with different forms of immune compromise. This study analyzes the chemokine signals and attracted immune cells in cerebrospinal fluid (CSF) during PML to define immune cell subpopulations relevant for the PML immune response. In addition to chemokines that indicate a general state of inflammation, like CCL5 and CXCL10, the CSF of PML patients specifically contains CCL2 and CCL4.
View Article and Find Full Text PDFBackground: Idiopathic scoliosis is common in adolescence. Due to the rapid growth of the spine, it must be monitored closely with radiographs to ensure timely intervention when therapy is needed. As these radiographs continue into young adulthood, patients are repeatedly exposed to ionizing radiation.
View Article and Find Full Text PDFArticle Synopsis
- About 20-40% of melanoma patients develop brain metastases, which makes treatment really hard.
- Researchers studied the genes and markers in these brain tumors to find new ways to help patients.
- They discovered that a certain protein called MET might help the tumors grow and avoid treatment, so targeting MET could be a good way to control these brain tumors.