Allocolchicinoids bearing a Michael acceptor fragment for possible irreversible binding of tubulin.

We describe an attempt to apply the concept of covalent binding towards the highly active allocolchicinoids selected on the basis of SAR analysis of previously synthesized molecules. To achieve the irreversible binding of the agent to the cysteine residues of the colchicine site of tubulin protein, we synthesized a number of new allocolchicinoids bearing the acceptor moiety. Some of the new derivatives possess cytotoxic activity against COLO-357, BxPC-3, HaCaT, and HEK293 cell lines in a low nanomolar range of concentrations.

[The interaction of dynamic speckles with suspensions of gram-negative cells].

The role of temporal coherence at photodynamic action of light on living cells was investigated. A mathematical model describing the interaction of low-coherent speckles with bacterial cells was suggested and its parameters were determined based on experimental data. The interrelation between the life time of dynamic optical speckles and the degree of photodestruction of illuminated cells was established by computer simulations.

[The wavelet analysis at heliobiological connections].

The Wavelet analysis of the time series of the number of insults per day and the variations of heliogeophysical indices was carried out. The patterns of Wavelet coefficients for both processes show a complex nonstationary behavior and the presence of periodic and acyclic constituents on different scales. During heliogeophysipal disturbances, the energy contribution to the processes increases more than threefold compared with the mean value on scales from three to five days.

[Effects of helio-geomagnetic disturbances on the human hemorheological characteristics].

Effects of geomagnetic disturbances on the rheological characteristics of blood and the homeostasis system were studies in 62 essentially healthy men. Rheological blood parameters, i.e.

[Response of the human body to heliogeophysical disturbanes].

A correlation between variations in the medical parameters and the heliogeophysical indices describing physical processes during solar storms was established. It was proposed that one of the reasons for the biotropic effects observed is rheological shifts of human blood during enhancement of solar activity. The influence of heliogeophysical disturbances on the rheological properties of blood was investigated.