The Effect of I155T, K156Q, K156E and N186K Mutations in Hemagglutinin on the Virulence and Reproduction of Influenza A/H5N1 Viruses.

The continued circulation of influenza A virus subtype H5 may cause the emergence of new potential pandemic virus variants, which can be transmitted from person to person. The occurrence of such variants is mainly related to mutations in hemagglutinin (HA). Previously we discovered mutations in H5N1 influenza virus hemagglutinin, which contributes to virus immune evasion.

[The Effect of I155T, K156Q, K156E and N186K Mutations in Hemagglutinin on the Virulence and Reproduction of Influenza A/H5N1 Viruses].

The continued circulation of influenza A virus subtype H5 may cause the emergence of new potential pandemic virus variants, which can be transmitted from person to person. The occurrence of such variants is mainly related to mutations in hemagglutinin (HA). Previously we discovered mutations in H5N1 influenza virus hemagglutinin, which contributes to virus immune evasion.

[Comparison of morbidity among working population in Russian regions with different modernization levels].

Based on complex of parameters characterizing social economic level, innovation activity and morbidity among able-bodied population, the authors suggested a typology of RF regions different in potential, urgency and risk value of modernization. Claster analysis helped to identify 4 types of territories - moderately modernizing regions with high modernization potential (12 RF subjects), well modernizing regions with moderate modernization potential (26 RF subjects), moderately modernizing regions with moderate modernization potential (28 RF subjects), poorly modernizing regions with low modernization potential (5 RF subjects). Findings are that special attention is required not only by RF subjects with the workers' low health level and poorly modernization processes, but also highly modernized regions with the workers' health problems can result from risky character of modernization.

The study of the interaction of (cytosine-5)-DNA methyltransferase SsoII with DNA by acoustic method.

The interaction of (cytosine-5)-DNA methyltransferase SsoII (M.SsoII) with double-stranded DNA was studied by means of thickness shear mode acoustic method (TSM) and gel electrophoresis. M.

Crystallization and preliminary crystallographic analysis of the (cytosine-5)-DNA methyltransferase NlaX from Neisseria lactamica.

Crystals of the (cytosine-5)-DNA methyltransferase NlaX from Neisseria lactamica (molecular weight 36.5 kDa) have been grown at 291 K using 2.5 M NaCl as precipitant.