Publications by authors named "E A Porcel"
Article Synopsis
- This work investigates a new cancer treatment strategy using porous metal-organic frameworks (nanoMOFs) combined with the anti-cancer drug Gemcitabine monophosphate (GemMP) and particle therapy, which improves precision in targeting tumors compared to traditional radiotherapy.
- The study addresses key challenges in cancer therapy, particularly the impact of hypoxia and the microenvironment around tumors, showing that GemMP-loaded nanoMOFs enhance the effectiveness of particle therapy in both oxygen-rich and oxygen-poor conditions while allowing for lower radiation doses.
- The research concludes that nanoMOFs significantly improve drug delivery to cancer cells, demonstrating potential for developing "all-in-one" nanodrugs that optimize treatment and increase the cytotoxic effects on hypoxic tumors.
Article Synopsis
- AGuIX nanoparticles are gadolinium-based agents that serve as both MRI contrast agents and enhance the effectiveness of X-ray radiation therapy for cancer treatment.
- A phase I trial tested the safety and optimal dosage of AGuIX in combination with conventional therapies for 12 patients with advanced cervical cancer, showing good tolerability and no severe side effects.
- The treatment resulted in complete remission of the primary tumors in all but one patient, highlighting the potential of these nanoparticles to improve the precision of tumor targeting and enhance radiotherapy outcomes.
We report the synthesis of biocompatible perfluorinated micelles designed to improve radiotherapeutic efficacy in a radioresistant tumor environment. In vitro and in vivo behaviors of perfluorinated micelles were assessed at both cellular and tissular levels. The micellar platform offers key advantages as theranostic tool: (i) small size, allowing deep tissue penetration; (ii) oxygen transport to hypoxic tissues; (iii) negligible toxicity in the absence of ionizing radiation; (iv) internalization into cancer cells; (v) potent radiosensitizing effect; and (vi) excellent tumor-targeting properties, as monitored by positron emission tomography.
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- Platinum nanoparticles (Pt NPs) show great promise in nanomedicine due to their high electron density and surface area, with intravenous injection being the preferred delivery method.
- Research using synchrotron radiation circular dichroism (SRCD) explored how these nanoparticles interact with human serum albumin (HSA), a key blood component, showing no strong complexation except for some increased thermal stability at a specific nanoparticle-to-protein ratio.
- The study suggests a quick method to assess the potential toxicity of Pt NPs for clinical use, particularly for intravenous applications.
Article Synopsis
- Recent clinical trials have started exploring the use of metallic nanoparticles (NPs) in radiotherapy for locally advanced cervical cancers, but current planning doesn't consider NP concentrations in target areas.
- A method was developed to assess the biological effects of NPs on radiation, involving a calibration phantom and advanced MRI techniques that quantified NP levels in four patients, compared against mass spectrometry results from biopsies.
- The study showed that NPs can enhance the effects of radiotherapy by about 15% at a dose of 2 Gy, positively influencing local tumor control, suggesting a need to integrate NP effects into future radiotherapy treatment plans.