Publications by authors named "E A Poplin"
Objectives: In 2013, the burials of 36 individuals of putative African ancestry were discovered during renovation of the Gaillard Center in downtown Charleston, South Carolina. The Charleston community facilitated a bioarchaeological and mitogenomic study to gain insights into the lives of these unknown persons, referred to as the Anson Street Ancestors, including their ancestry, health, and lived experiences in the 18th century.
Methods: Metric and morphological assessments of skeletal and dental characteristics were recorded, and enamel and cortical bone strontium stable isotope values generated.
Purpose: Patients with metastatic colorectal cancer refractory to chemotherapy have limited treatment options. Ensituximab (NEO-102) is a novel chimeric mAb targeting a variant of with specificity to colorectal cancer.
Patients And Methods: Single-arm, phase II trial assessed the efficacy and safety of ensituximab in patients with advanced, refractory cancer who expressed antigen in tumor tissue.
Article Synopsis
- The study focused on the effectiveness of a combination treatment of nab-paclitaxel, gemcitabine, and cisplatin in 25 patients with metastatic pancreatic ductal adenocarcinoma, given its DNA repair deficiencies and potential sensitivity to DNA-damaging agents.
- Conducted from December 2013 to January 2018, the clinical trial assessed patient responses based on established measurement criteria, with a primary focus on complete response rates and safety profiles.
- Results showed that the treatment had significant side effects, with many patients experiencing severe adverse events, and 12% of participants had fatal outcomes related to the treatment.