Spontaneous and mitogen-induced cytokine production in lymphoproliferative diseases.

The levels of spontaneous and mitogen-induced production of pro- and anti-inflammatory cytokines were studied in patients with chronic lymphoid leukemia, non-Hodgkin's lymphocytic lymphomas, and multiple myeloma during the course of chemotherapy. Cytokine concentrations varied within a great range and did not conform to the normal distribution law. The levels of granulocyte and granulocyte-macrophage CSF were high during the debut, progress, and remission of the lymphoproliferative diseases.

Morphometric study of trephine biopsy specimens in aggressive and indolent non-Hodgkin's lymphomas.

Morphometric study of the erythroid stem was performed in aggressive and indolent non-Hodgkin's lymphomas vs. other cells and tissues of the bone marrow (including the tumor tissue) before chemotherapy. Hypoplasia and abnormal maturation of the erythroid stem were particularly pronounced in diffuse infiltration of the bone marrow, which did not depend on lymphoma aggressiveness.

Morphological characteristics of the central compartment of the erythron in aggressive and indolent non-Hodgkin's lymphomas.

Structural changes in cells of the central compartment of the erythron depended on tumor infiltration of the bone marrow. Cytostatic therapy was shown to improve quantitative indexes, but had no effect on morphological characteristics of the erythron. Examination of trepanobiopsy specimens from the iliac crest during chemotherapy revealed the existence of specific relationships between the erythron, other cells and tissues of the bone marrow, and tumor.

Changes in bone marrow and peripheral compartments of the erythron under the effect of tumor cells in indolent non-Hodgkin lymphomas and multiple myeloma.

Here we present the results of pathomorphological study of erythron cells from patients with indolent non-Hodgkin lymphomas and multiple myeloma. The revealed associations suggest that tumor cells can modulate the bone marrow and peripheral compartment of the erythron in lymphoproliferative diseases leading to quantitative and morphological changes in bone marrow erythrokaryocytes and peripheral blood erythrocytes. Clinical and pathomorphological markers of dyshemopoiesis associated with the presence of anemia were identified in indolent non-Hodgkin lymphomas.