Publications by authors named "E A Pastorello"
Repeated HyperArc radiosurgery for recurrent intracranial metastases and dosimetric analysis of recurrence pattern to account for diffuse dose effect on microscopical disease.
Clin Transl Radiat Oncol
September 2024
Aims: Evaluate effectiveness and safety of multiple HyperArc courses and patterns of progression in patients affected by BMs with intracranial progression.
Methods: 56 patients were treated for 702 BMs with 197 (range 2-8) HyperArc courses in case of exclusive intracranial progression. Primary end-point was the overall survival (OS), secondary end-points were intracranial progression-free survival (iPFS), toxicity, local control (LC), neurological death (ND), and whole-brain RT (WBRT)-free survival.
Article Synopsis
- The study investigates how stereotactic body radiation therapy (SBRT) affects lymph-nodal prostate cancer oligometastases, focusing on the different treatment outcomes between pelvic and para-aortic lymph nodes.
- A total of 240 lymph-nodal oligometastases from 164 patients were analyzed, revealing a median progression-free survival (PFS) of 20 months for pelvic cases versus 11 months for para-aortic cases, although this difference wasn’t significant in further analyses.
- The findings indicate that while patients with para-aortic disease may have comparable PFS to those with pelvic disease, both groups demonstrate high local control rates, suggesting SBRT is beneficial for treating para-aortic metastases.
Background: Stereotactic radiotherapy (SRT) and Proton therapy (PT) are both options in the management of liver lesions. Limited clinical-dosimetric comparison are available. Moreover, dose-constraint routinely used in liver PT and SRT considers only the liver spared, while optimization strategies to limit the liver damaged are poorly reported.
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- * The study involved 214 patients with noted hazelnut allergies, assessing their sensitization to specific hazelnut proteins (Cor a 1, Cor a 8, and Cor a 9) and found that those monosensitized to Cor a 8 had more severe allergic reactions compared to those sensitized to Cor a 1 or both proteins.
- * Results suggest that multiple sensitivities impact the severity of reactions, with patients who are only sensitized to Cor a 8 experiencing more frequent and intense system reactions than those with broader
Introduction: To evaluate prostate volume change during daily-adaptive prostate SBRT on 1.5 T MR-linac and to correlate it with treatment toxicity.
Methods: a series of patients affected by low-to-intermediate risk prostate cancer was treated by 5-fraction SBRT within a prospective study (Prot.