The Role of Innate Priming in Modifying Tumor-associated Macrophage Phenotype.

Tumor-associated macrophages (TAMs) are innate immune cells that exert far reaching influence over the tumor microenvironment (TME). Depending on cues within the local environment, TAMs may promote tumor angiogenesis, cancer cell invasion and immunosuppression, or, alternatively, inhibit tumor progression via neoantigen presentation, tumoricidal reactive oxygen species generation and pro-inflammatory cytokine secretion. Therefore, TAMs have a pivotal role in determining tumor progression and response to therapy.

Mobility in a cardiac surgery intensive care unit: A behaviour mapping study.

Purpose: Mobilization within 24 h post-cardiac surgery (CS) supports improved patient health outcomes. Despite being safe and recommended, it is unknown how much mobility takes place post-CS in the intensive care unit (ICU). Behaviour mapping was used to describe patterns of patients' mobility in one CS ICU.

Foraging and inertia: understanding the developmental dynamics of overt visual attention.

During early life, we develop the ability to choose what we focus on and what we ignore, allowing us to regulate perception and action in complex environments. But how does this change influence how we spontaneously allocate attention to real-world objects during free behaviour? Here, in this narrative review, we examine this question by considering the time dynamics of spontaneous overt visual attention, and how these develop through early life. Even in early childhood, visual attention shifts occur both periodically and aperiodically.

Paving the way for quality assured, decentralised point-of-care testing for infectious disease in primary care - Real world lessons from remote Australia.

Introduction: Decentralized molecular testing for infectious disease diagnosis at the point-of-care (POC) is critical to address inequities in access to timely, informed health care. The COVID-19 pandemic accelerated the demand, development and adoption of POC tests for infectious diseases globally. This has provided opportunities to maximize the individual benefits and public health impact of POC testing, particularly in remote and resource-limited primary care settings.

A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent.

Berberine, an isoquinoline alkaloid derived from various medicinal plants, emerges as a potential therapeutic agent against diverse human diseases. It has particularly shown notable anticancer efficacy against breast, colorectal, lung, prostate, and liver cancer. Berberine results in inhibition of cancer cell proliferation, induction of apoptosis, and suppressing angiogenesis, positioning it as a versatile, multitargeted therapeutic tool against cancer.