Publications by authors named "E A Orlov"
Article Synopsis
- Embryonic scaling is a unique biological phenomenon where embryos adjust their spatial structure according to their size, initially described in sea urchins.
- Recent research has aimed to understand the role of specific genes, termed "scalers," which are crucial in regulating morphogen concentration gradients in correlation with embryo size.
- The findings confirm that scalers, including the gene Mmp3, exist in various reaction-diffusion system models and play a vital role in maintaining gradient scaling across different embryonic types.
The aim of this article was to assess the flow capacity of end-to-side arterial anastomosis depending on the method of its implementation. The study was conducted on 30 live Wistar rats in vivo, which were randomly divided into three groups. In each group of animals, an end-to-side microanastamosis was performed using three methods of donor artery preparation: 45 degrees (group A), 90 degrees (group B), and arteriotomy according to the "fish mouth" type (group C).
View Article and Find Full Text PDFJOURNAL/nrgr/04.03/01300535-202509000-00024/figure1/v/2024-11-05T132919Z/r/image-tiff The process of neurite outgrowth and branching is a crucial aspect of neuronal development and regeneration. Axons and dendrites, sometimes referred to as neurites, are extensions of a neuron's cellular body that are used to start networks.
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- During gastrulation and neurulation in vertebrate embryos, the chordamesoderm and neuroectoderm converge and extend under a genetic program.
- This study investigates whether mechanical tension from these movements influences gene expression in these tissues.
- By analyzing stretched midgastrula embryo explants, researchers found that mechanical stretching activates certain genes in the stretched trunk region while inhibiting others in low-stretch areas, suggesting that mechanical forces could regulate embryonic patterning and development.
The purpose of our study is to develop age-related phosphorylated tau (p-tau) inhibitors, for Alzheimer's disease (AD). There are wide-ranging therapeutic molecules available in the market and tested for age-related p-tau inhibition to enhance phosphatase activity and microtubule stability in AD neurons. Until now there are no such small molecules claimed to show promising results to delay the disease process of AD.
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