Disjoining Pressure Decay Length in Room-Temperature Ionic Liquids: A Molecular Simulation Study.

We present all-atom molecular simulations to investigate the behavior of 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF]) in negatively charged carbon nanopores of different widths ( = 5÷15 nm) and lengths ( = 4÷10 nm). The goal of our study was to determine how the disjoining pressure varies as a function of the pore width at different lengths and to understand the influence of edge effects. Our results show that the edge effect decreases as the pore length increases.

SARS-CoV-2 Subunit Virus-like Vaccine Demonstrates High Safety Profile and Protective Efficacy: Preclinical Study.

Public health threat coming from a rapidly developing COVID-19 pandemic calls for developing safe and effective vaccines with innovative designs. This paper presents preclinical trial results of "Betuvax-CoV-2", a vaccine developed as a subunit vaccine containing a recombinant RBD-Fc fusion protein and betulin-based spherical virus-like nanoparticles as an adjuvant ("Betuspheres"). The study aimed to demonstrate vaccine safety in mice, rats, and Chinchilla rabbits through acute, subchronic, and reproductive toxicity studies.

Molecular origin of structural defects in the zinc phthalocyanine film.

Controlling the growth of thin phthalocyanine films is a long-term challenge for the science of applied nanomaterials. So, this contribution deals with films of unsubstituted zinc phthalocyanine (ZnPc) and seeks to acquire structural information that is unavailable physical experiments, thus, finding out how the film morphology can be seriously improved. A model of the vapor-deposited film has been created using the molecular dynamics method.

Missense Mutations in Desmoplakin Plakin Repeat Domains Have Dramatic Effects on Domain Structure and Function.

Plakin repeat domains (PRDs) are globular modules that mediate the interaction of plakin proteins with the intermediate filament (IF) cytoskeleton. These associations are vital for maintaining tissue integrity in cardiac muscle and epithelial tissues. PRDs are subject to mutations that give rise to cardiomyopathies such as arrhythmogenic right ventricular cardiomyopathy, characterised by ventricular arrhythmias and associated with an increased risk of sudden heart failure, and skin blistering diseases.

Features of Housing Provision for Rural and Urban Populations.

The results of assessing the housing provision of the rural and urban populations of Russia are presented. On the basis of the author's methodology for identifying the level of housing provision, its actual characteristics were compared with social standards, that is, regulatory requirements for area, spaciousness, and comfort of a house or apartment. It is shown that in the city, in contrast to the countryside, housing conditions are characterized by a higher level of comforts but, at the same time, more constrained living conditions (in terms of the area of the dwelling and its spaciousness).