Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity.

Longevity medicine is an emerging and iterative healthcare discipline focusing on early detection, preventive measures, and personalized approaches that aim to extend healthy lifespan and promote healthy aging. This comprehensive review introduces the innovative concept of the "." This conceptual framework delineates progressive intervention levels, providing a structured approach to understanding the diverse strategies available in longevity medicine.

Small-molecule disruption of androgen receptor-dependent chromatin clusters.

Sustained androgen receptor (AR) signaling during relapse is a central driver of metastatic castration-resistant prostate cancer (mCRPC). Current AR antagonists, such as enzalutamide, fail to provide long-term benefit for the mCRPC patients who have dramatic increases in AR expression. Here, we report AR antagonists with efficacy in AR-overexpressing models.

Validation of capture reactions cross sections in Cf(s.f.) neutron field.

We have investigated following capture reactions: Au(n,g)Au, Cu(n,g)Cu, Sc(n,g)Sc, Ta(n,g)Ta, Ce(n,g)Ce, La(n,g)La, Yb(n,g)Yb, Mn(n,g)Mn, and Pr(n,g)Pr in a standard Cf(s.f.) neutron field.

The impact of cross-linker distribution on magnetic nanogels: encapsulation, transport and controlled release of the tracer.

Magnetic nanogels (MNGs) are highly attractive for biomedical applications because of their potential for remote control of the rheology and internal structure of these soft colloids with biocompatible magnetic fields. In this contribution, using molecular dynamics simulations, we investigate the impact of the cross-linker distribution in the body of a MNG on the shape and magnetic response to constant and AC magnetic fields and relate those properties to the behaviour of non-magnetic tracers placed in the MNGs and left to escape. We find that if no AC magnetic field is applied, although the escape times of the tracer particles barely depend on morphology, the highest degree of subdiffusion is observed for the gels with a non-uniform cross-linkerer distribution.

Measurement of neutron spectra in spent fuel storage.

The neutron spectrum was measured at two locations in the spent fuel storage facility of the Temelín nuclear power plant. The measurement had two primary objectives: to map the neutron -γ field by quantifying the ambient dose equivalent H∗(10) and to identify methods that could improve the quality of the adjusted neutron spectrum using a Bonner Sphere Spectrometer (BSS). Three spectrometers were used: a BSS and two proton recoil spectrometers.