Publications by authors named "E A Nikolaev"
Introduction: Identifying early risks of developing Alzheimer's disease (AD) is a major challenge as the number of patients with AD steadily increases and requires innovative solutions. Current molecular diagnostic modalities, such as cerebrospinal fluid (CSF) testing and positron emission tomography (PET) imaging, exhibit limitations in their applicability for large-scale screening. In recent years, there has been a marked shift toward the development of blood plasma-based diagnostic tests, which offer a more accessible and clinically viable alternative for widespread use.
View Article and Find Full Text PDFMicroalgae are active producers of various compounds, including toxic substances. However, their metabolism is very diverse and insufficiently known. We demonstrate an approach that includes growing a new strain of cyanobacterium Leptolyngbya sp.
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- Accumulation of beta-amyloid peptides (Aβ) and their modifications, particularly phosphorylated serine-8 (pSer8-Aβ), are key factors in the progression of Alzheimer's disease (AD), influencing neuronal degradation and cytotoxicity.* -
- The study found that pSer8-Aβ levels in the brains of 5xFAD mice steadily increase from 3 months to 14-17 months, paralleling the general accumulation of Aβ peptides, and that pSer8-Aβ constitutes up to 1-10% of total Aβ in the cerebrospinal fluid of AD patients.* -
- Mass spectrometry confirmed the possibility of specific Aβ phosphorylation in brain tissues, suggesting
Article Synopsis
- The study investigated the presence of anti-podocyte antibodies, specifically targeting synaptopodin and annexin 1, in patients with nephrotic syndrome to evaluate their role in diagnosing primary podocytopathies like Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS).
- A total of 72 nephrotic syndrome patients were analyzed, alongside 21 healthy individuals, finding higher antibody levels in MCD and FSGS patients compared to the others, indicating their potential use in diagnosis.
- The combined analysis of both antibody types showed significant diagnostic accuracy (sensitivity of 80.9% and specificity of 81.3%), although these antibody levels did not predict how well patients
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- Schizophrenia affects brain structure and function, with research focusing on both anatomical and molecular changes, particularly in lipids and metabolites.
- A spatial analysis of lipid composition in specific neocortical regions (BA9 and BA22p) aims to understand how schizophrenia alters lipid profiles in gray and white matter.
- Findings indicate that lipid changes are distributed unevenly, with more pronounced differences in the subcortical white matter of BA22p compared to BA9, revealing varying impacts on lipid classes between regions and tissue types.