Publications by authors named "E A Neugebauer"
Zygotic genome activation (ZGA) is crucial for maternal to zygotic transition at the 2-8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In humans, ZGA is induced by DUX4, a pioneer factor that drives expression of downstream germline-specific genes and retroelements. Here we show that herpesviruses from all subfamilies, papillomaviruses and Merkel cell polyomavirus actively induce DUX4 expression to promote viral transcription and replication.
View Article and Find Full Text PDFEffective population size () is one of the most important parameters in evolutionary biology, as it is linked to the long-term survival capability of species. Therefore, greatly interests conservation geneticists, but it is also very relevant to policymakers, managers, and conservation practitioners. Molecular methods to estimate rely on various assumptions, including no immigration, panmixia, random sampling, absence of spatial genetic structure, and/or mutation-drift equilibrium.
View Article and Find Full Text PDFArticle Synopsis
- - Sepsis is a severe condition that can cause death and is particularly risky for older adults and those with underlying health issues; around 90,000 people die from sepsis annually in Germany.
- - The SepWiss project aims to improve public awareness of sepsis and the importance of vaccinations through a targeted information campaign in Berlin and Brandenburg, focusing on high-risk groups.
- - The effectiveness of the campaign will be assessed by comparing vaccination rates and sepsis knowledge in the intervention area against a control region, along with a mixed-method evaluation of the campaign's implementation.
Objectives: The aim of this billing data analysis was to examine the implementation of the second opinion directive in Germany and to investigate how often informing patients about their right to a second opinion (SO) and obtaining a SO are documented.
Methods: To examine the frequency of "informing about SO" and "obtaining an SO", insured patients who received an indication for tonsillectomy, tonsillotomy or hysterectomy in 2019 or 2020 were included, as well as insured patients who received an indication for shoulder arthroscopy in Q2-Q3 2020. Data were analyzed descriptively.
Unlabelled: We examined the prevalence of obesity in two types of schools-a comprehensive school and a grammar school-in a rural German region of Brandenburg.
Methods: In a cross-sectional study, BMI values were measured in 114 students in grades 5, 7, and 10. In addition to the demographic data, data on nutrition, physical activity, and mental well-being were collected using a questionnaire.