[Adrenalectomy changes diazepam performance in male and female rats under multiparametric test conditions].

It is established that adrenalectomy decreases the "sedative" and "anti-anxiety" effects and reduces the "anxiogenic" effect of diazepam in male rats under multiparametric test conditions. At the same time, the "sedative" and "activating" effects of this tranquilizer do not appear in adrenalectomized female rats and the "anti-anxiety" effect is only observed in the evening. The "anxiogenic" effect of diazepam in females is not observed for a drug dose of 0.

[Stress effect on haloperidol-induced catalepsy and its circadian rhythm in intact and ovariectomized female rats].

Stressing reduces the intensity of haloperidol-induced catalepsy in intact female rats and increases it in ovariectomized animals. Ovarioectomy reduces the severity of haloperidol catalepsy. Circadian rhythm acrophase of the cataleptogenic haloperidol activity in female rats after ovariectomy and stress exhibits significant displacement.

[Chronobiological distinctions in swimming behaviour of intact and ovariectomised rats females].

The forced swimming (experimental model of depression) of intact and ovarioectomized rats-females using chronobiological approach was investigated. "The index of depression" of intact rats-females in a stage of proestrus/estrus was a little higher than in diestrus 1/2 in the morning and evening was established. Thus "the index of depression" in evening time was great.

[Sexual distinctions of the diazepam activity in rats in the conflict situation].

Diazepam caused less pronounced shifts in the conflict situation test in female rats as compared to males. The drug produced more pronounced anticonflict action on male rats in the evening. In female rats, a doze of 0.