Publications by authors named "E A M Kouwert"
Catatonia is one of the most severe psychiatric syndromes, and clinical symptoms and etiology are very heterogeneous. When accompanied by autonomic instability and hyperthermia it’s termed malignant catatonia, which left untreated is associated with significant morbidity and mortality. First-line treatment is high dose benzodiazepines, followed by electroconvulsive therapy (ECT), in case of non-response.
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- Methylphenidate (MPH) is commonly prescribed for attention-deficit/hyperactivity disorder, but some patients require unusually high doses, possibly due to genetic differences affecting drug metabolism.
- A study involving three patients taking doses between 180 to 640 mg of MPH found that their plasma concentrations were lower than expected, indicating a faster metabolism of the drug.
- However, genetic testing of the CES1 gene did not reveal any variants that could account for the increased clearance of MPH in these patients, suggesting other factors may be involved in their high dosage needs.
We investigated whether personality and nonverbal interpersonal processes can predict the subsequent response to light treatment in seasonal affective disorder (SAD) patients. In 60 SAD patients, Neuroticism and Extraversion were assessed prior to light treatment (4 days with 30 min of 10.000 lux).
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