[Pathogenetic approaches to the correction of vascular homeostasis in patients with COVID-19: A review].

The adverse outcomes in patients with COVID-19 in the initial phase of the disease are often due to the development of cytokine storm, endothelial dysfunction, shifts in the hemostasis system, microangiopathy, angiocentric inflammation, and pathological angiogenesis, which require targeted therapy. Unfortunately, to date, there is still no drug with proven high efficacy. This review is to analyse the literature data on the pathogenesis of vascular homeostasis lesions and possible ways to correct the existing shifts in patients with COVID-19.

Structural diversity of leukotriene G-protein coupled receptors.

Dihydroxy acid leukotriene (LTB) and cysteinyl leukotrienes (LTC, LTD, and LTE) are inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase pathway. While structurally similar, these two types of leukotrienes (LTs) exert their functions through interactions with two distinct G protein-coupled receptor (GPCR) families, BLT and CysLT receptors, which share low sequence similarity and belong to phylogenetically divergent GPCR groups. Selective antagonism of LT receptors has been proposed as a promising strategy for the treatment of many inflammation-related diseases including asthma and chronic obstructive pulmonary disease, rheumatoid arthritis, cystic fibrosis, diabetes, and several types of cancer.

Structural basis for receptor selectivity and inverse agonism in S1P receptors.

The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) - S1P. S1P is predominantly expressed in nervous and immune systems, regulating the egress of natural killer cells from lymph nodes and playing a role in immune and neurodegenerative disorders, as well as carcinogenesis. Several S1PR therapeutic drugs have been developed to treat these diseases; however, they lack receptor subtype selectivity, which leads to side effects.

[The social and medical problems of childhood psychiatry].

The purpose of the study is to to identify key social and medical problems of childhood psychiatry by analysis of statistical and clinical data of Moscow health care institutions. It is established that actual problems are related to increasing of incidence of morbidity of mental disorders in children, their late detection, absence or unavailability of diagnostic techniques with high evidentiary effect, inability to use modern achievements of psychopharmacotherapy, close relationship of mental disorders with social factors, as well as with high stigmatization of mental health sphere. It is necessary to intensify research in studying etiopathogenetic factors, elaborating strategies of mental disorders prevention in childhood, clinical trials targeted to expand age range of application of medications and to icrease activities on destigmatization and psychoeducation in society.

Poplar tree (Populus balsamifera L.) as indicator of mercury emission from a point source.

The article provides original data on the ecological and geochemical characteristics of the distribution of Hg in the leaves and annual rings of balsam poplar (P. balsamifera L.) in the zone of influence of lithium production (Novosibirsk).