Publications by authors named "E A Lilly"
Article Synopsis
- Urinary tract infections (UTIs) are common in emergency departments, and this study evaluated the necessity of broad-spectrum treatment for hospitalized patients with community-acquired UTIs (CAUTIs).
- Conducted over two years at a major Lebanese tertiary care center, the study analyzed data from adult patients to determine treatment adherence, characteristics of CAUTIs, and risks associated with extended spectrum beta-lactamase (ESBL) infections.
- Results indicated that most patients received appropriate ESBL-targeting treatment, but 46% required adjustments, emphasizing the need for better monitoring of drug-resistant bacteria and stronger local treatment guidelines.
Introduction: The development of certain immune-mediated diseases (IMD) in patients with inflammatory bowel diseases [IBD; Crohn's disease (CD), ulcerative colitis (UC)] has been linked to treatment of IBD. Hair loss in some patients may be due to immune-mediated alopecia areata (AA). Risk factors and outcomes of AA in patients with IBD have not been previously explored.
View Article and Find Full Text PDFTelomeres are conserved chromosomal structures necessary for continued cell division and proliferation. In addition to the classical telomerase pathway, multiple other genes including those involved in ribosome metabolism and chromatin modification contribute to telomere length maintenance. We previously reported that Arabidopsis thaliana ribosome biogenesis genes OLI2/NOP2A, OLI5/RPL5A and OLI7/RPL5B have critical roles in telomere length regulation.
View Article and Find Full Text PDFArticle Synopsis
- - Myhre syndrome is a rare genetic disorder linked to mutations in the SMAD4 gene, with recent studies from Massachusetts General Hospital highlighting its complexities through evaluations of 47 patients.
- - The findings indicate that symptom progression occurs in all patients after at least 5 years of observation, with different SMAD4 variants associated with varying health outcomes, particularly regarding hearing loss and aortic hypoplasia.
- - There is a call for more research and evidence-based guidelines to improve understanding and treatment of Myhre syndrome, especially given the serious complications observed, including deaths related to cardiovascular issues.