Publications by authors named "E A Lesovaya"
Article Synopsis
- Ribavirin and its modified versions were found to have a significant effect on inhibiting the growth of cancer cells, particularly leukemia cells.
- Researchers synthesized several derivatives of ribavirin, specifically targeting their structural positions to evaluate their antiproliferative and antimicrobial properties, showing that some were effective against both Gram-positive and Gram-negative bacteria.
- The most promising derivative, n-decyloxymethyl, was shown to kill leukemia cells at low doses by disrupting cell cycle progression and potentially inhibiting critical cellular processes involved in cancer growth.
Article Synopsis
- * Current treatments primarily involve surgical resection for localized cases, with chemotherapy and radiotherapy as adjuncts, while targeted therapies remain limited.
- * There is a growing interest in exploring molecular characteristics of SS subtypes to identify new treatment targets, with innovative approaches including immune-based therapies and epigenetic modifiers being researched.
Int J Mol Sci
August 2024
Article Synopsis
- Glucocorticoids (GCs) are commonly used to treat blood cancers but can cause various side effects due to how they interact with glucocorticoid receptors (GRs).
- Selective GR agonists (SEGRAs) like CpdA aim to enhance the beneficial anticancer effects while minimizing side effects; however, CpdA faces challenges with chemical instability.
- The newly developed derivative, CpdA-03, shows improved stability and GR affinity, demonstrating significant anticancer activity in lymphoma models, with a tripling reduction in tumor volume compared to conventional treatments.
Cardiovasc Pathol
September 2024
Article Synopsis
- * Anthracyclines, particularly doxorubicin, are effective in fighting tumors but can cause serious heart damage, known as cardiotoxicity.
- * Understanding how doxorubicin affects heart function is essential for creating new protective strategies against its harmful impacts on the cardiovascular system.
Cancers (Basel)
January 2024
Article Synopsis
- - Liposarcoma (LPS) is a prevalent type of soft-tissue sarcoma in adults, showcasing diverse histological features and varying molecular abnormalities, complicating treatment options.
- - Current treatment mainly relies on surgical removal for localized cases, but many patients face advanced, unresectable, or metastatic disease, highlighting a need for better-targeted therapies.
- - Research into the molecular genetics and specific signaling pathways of liposarcoma is paving the way for innovative treatments, with encouraging results from certain targeted therapies like multi-kinase inhibitors anlotinib and sunitinib.
