Publications by authors named "E A Leibold"

2-Phenoxyethanol (PhE) is an amphiphilic organic compound frequently used as a broad-spectrum preservative in cosmetic products and other consumer goods. PhE is also used as a biocidal component in occupational settings. A previous volunteer study by our working group following oral exposure to PhE showed that PhE is almost completely taken up into the human body followed by an extensive metabolization and fast urinary elimination.

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UV-P (2-(2H-Benzotriazol-2-yl)-p-cresol) is used as an ultraviolet (UV) light absorber in coating products, paints, adhesives, and sealants. Due to its widespread industrial and consumer uses, human exposure to UV-P is conceivable. In the study presented herein, initial data on its human in vivo metabolism were obtained for three study participants after single oral administration of 0.

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Article Synopsis
  • 2-Phenoxyethanol (PhE) is widely used in various products, including pharmaceuticals and cosmetics, but its effects on human metabolism and toxicity are not well understood.
  • A pilot study administered PhE to five volunteers, collecting blood and urine samples to analyze its metabolism over 48 hours, with one volunteer undergoing a separate skin exposure.
  • Results showed that PhE is quickly absorbed and metabolized, primarily into phenoxyacetic acid and 4-hydroxyphenoxyacetic acid, with most of the substance excreted in urine within 48 hours, providing important data for assessing human exposure and pharmacokinetics.
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2-Phenoxyethanol (PhE) is widely used as a preservative in consumer products such as cosmetics as well as at the workplace as a component of metal-working fluids and hydraulic fluids. Therefore, both industry workers and consumers may potentially be exposed to PhE. An analytical method for the quantification of PhE and three selected metabolites, namely phenoxyacetic acid (PhAA), 4-hydroxyphenoxyacetic acid (4-OH-PhAA), and 4-hydroxyphenoxyethanol (4-OH-PhE), in human urine and blood was developed and validated.

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Article Synopsis
  • Geraniol is a rose-scented fragrance found in natural terpene oil and used in cosmetics, personal care products, and food as an additive.
  • An experimental study assessed how the body processes and eliminates geraniol by analyzing urine samples from three subjects after ingesting two dosages of geraniol.
  • The study identified four main metabolites in urine, with Hildebrandt acid being the most abundant, and provided estimates for daily geraniol uptake among non-exposed adults.
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