Biodegradation of Resorbable Magnesium Alloys Promising for Implant Development.

Unlabelled: was to study the biodegradation characteristics and rate of magnesium alloys .

Materials And Methods: We studied the biodegradation of magnesium alloys Mg-Zn-Ca and WE43 (Mg-Y-Nd-Zr) in homogenized (initial) condition and after strengthening by mechanical processing using equal channel angular pressing (ECAP). The samples were incubated in a model system based on reference fetal calf serum (FCS) in the static and dynamic modes.

Anti-tumour activity of Mg-6%Ag and Mg-10%Gd alloys in mice with inoculated melanoma.

Cytotoxicity in vitro and anti-tumour activity in vivo of magnesium alloys Mg-6%Ag and Mg-10%Gd was studied. It was shown that specifically designed and thermomechanically processed Mg alloys produced a sizeable cytotoxic effect on PC-3 line tumour cells in vitro through inhibition of their proliferation. A pronounced grain refinement in combination with the formation of second phases and precipitates attained by means of equal-channel angular pressing (ECAP) accellerated the degradation and gave rise to enhanced anti-tumour activity of both alloys.