[Prognostic value of structural-functional characteristics of skin melanoma].

Surgical material is investigated. Morphometric criteria of ultrastructural atypia are considered as a possible prognostic factor of melanoma lymphogenic metastases. This allows detection of skin melanoma with high metastatic potential.

[Morphopathology of cerebral arteries in combined cerebral and coronary atherosclerosis].

Taking into consideration the age-specific and adaptive changes of the vascular wall, pathomorphologic features of cerebral atherosclerosis were revealed in 236 individuals who died of ischemic heart disease and in 17 patients undergone extra-intracarotid microshunting on the basis of the data obtained from pathomorphologic analysis of the great arteries of the brain. There was a statistically significant prevalence of both the size of the area of atherosclerotic lesions and the incidence of stenosis of the great arteries of the brain in individuals with combined atherosclerosis of cerebral and coronary atherosclerosis. Type-specific peculiarities of atherosclerosis in the areas of reduced blood flow in stenosis of extra- and intracranial arteries were determined.

[The efficacy of different salt diets and the modulation of the protective action of cerebrolysin in an experimental disturbance of the cerebral circulation].

Experiments on rats showed that long-term excess sodium chloride feeding increased the loss of animals as a result of the common carotid artery ligation. The effect is related to maximum decrease in the local cerebral blood flow and sharply pronounced brain swelling. The sodium chloride substitute giposol reduced the extent of cerebral ischemia and produced antiswelling effect.