[Autoimmune encephalitis: psychiatric aspects].

Autoimmune encephalitis is a group of diseases researched by both neurologists and psychiatrists. Despite a large number of studies and practical recommendations, the differential diagnosis and early diagnostics still remains an important issue. The most difficult to diagnose are cases that debut as mental disorders and/or occur without neurological symptoms.

Dependence of blood biochemical parameters on various genotypes of the UGT1A1 gene associated with gilbert's syndrome.

Diagnosis of Gilbert's syndrome is based on the detection of homozygous carriage of an additional TA-repeat in the promoter of the UGT1A1 gene, leading to a decrease in the activity of the UGT enzyme. No large studies have been done in the Russian Federation on the prevalence of carriage of Gilbert's syndrome, as well as the biochemical and molecular profile of such patients. The aim of the study is to evaluate biochemical and molecular genetic parameters in patients with Gilbert's syndrome in Russia.

[Testing the acceptability of applied reference intervals, by using serum creatinine as an example].

Unfortunately, the international standard ISO 15189:2003 does not give clear guidelines for the choice, development, and testing the acceptability of reference intervals. The so-called normalization of the frequency distribution of serum creatinine concentrations was carried out in the population of outpatients above 18 years of age. Creatinine concentrations were measured, using 5 analytical systems: Abbott Architect (n=9054), Roche Modular (n = 22,947), Roche Integra 400 (n=2748), Roche Integra 700 (n=8350), and Roche Hitachi (n = 20,196).

[The estimated glomerular filtration rate in outpatients].

The glomerular filtration rate (GFR) calculated by the MDRD formula was estimated in a population of outpatients aged over 18 years. Serum creatinine concentrations were measured, by using 5 analytical systems: Abbott Architect (n = 9054), Roche Modular (n = 22947), Roche Integra 400 (n = 2748), Roche Integra 700 (n = 8350), and Roche Hitachi (n = 20196). For 4 systems, the distribution of GFR differed little.