Publications by authors named "E A Koltsova"
Hepatocellular carcinoma (HCC) is an aggressive primary liver malignancy often diagnosed at an advanced stage, resulting in a poor prognosis. Accurate risk stratification and early detection of HCC are critical unmet needs for improving outcomes. Several blood-based biomarkers and imaging tests are available for early detection, prediction, and monitoring of HCC.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) is a leading cause of cancer mortality globally. Most patients present with late diagnosis, leading to poor prognosis. This narrative review explores novel biomarkers for early HCC detection.
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- Umbilical cord blood's use in hemostasis testing for newborns is under-researched, leading to this study aimed at evaluating its applicability compared to venous blood samples.
- The study involved 187 newborns and found that umbilical cord blood exhibited a hypocoagulable shift in clotting times and fibrinogen levels, while thromboelastometry and thrombodynamics showed a hypercoagulable shift in newborn blood.
- The differences in hemostatic parameters highlight that newborns have distinct coagulation profiles compared to adults, with implications for understanding their physiological and pathological hemostatic features.
Pathologies such as malaria, hemorrhagic stroke, sickle cell disease, and thalassemia are characterized by the release of hemoglobin degradation products from damaged RBCs. Hematin (liganded with OH) and hemin (liganded with Cl)-are the oxidized forms of heme with toxic properties due to their hydrophobicity and the presence of redox-active Fe. In the present study, using the original LaSca-TM laser particle analyzer, flow cytometry, and confocal microscopy, we showed that both hematin and hemin induce dose-dependent RBC spherization and hemolysis with ghost formation.
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