Perforation of sigmoid colon by a migrated intrauterine contraceptive device (IUCD), diagnosis and surgical management: a case report.

We describe the case of a 43-year-old woman presented with an 8-month history of intermittent non-specific abdominal pain. She had an Intrauterine Contraceptive Device (IUCD) inserted 4-years ago and the device was still in-situ. After initial gynaecological assessment, further clinical radiological investigations, computerized tomography imaging showed that the intraluminal part of the radiological foreign body was seen to be possibly perforating the sigmoid colon after having migrated.

Marijuana Use Is Associated with Increased Rates of Hip Dislocation and Lower Insurance Reimbursement among Total Hip Arthroplasty Recipients.

This study utilizes an all-payer database to compare 90-d and 1-year outcomes between marijuana and non-marijuana users undergoing total hip arthroplasty (THA). The primary aim of this study focused on 90-d and 1-year opioid consumption among marijuana users and non-users who underwent THA. Our secondary aim focused on comparing 90-d and 1-year rates of readmissions, revisions and adverse events between the two groups.

[Localization features of FAP-positive activated stromal cells in fibrosis in patients with new coronavirus infection COVID-19].

Objective: To evaluate the representation and localization of FAP-positive activated stromal cells depending on the severity of fibrotic changes in tissues of patients with a confirmed diagnosis of COVID-19.

Material And Methods: 20 autopsy observations of patients who died from COVID-19 were studied. Immunohistochemical studies were performed using antibodies to CD90, FAP and aSMA and a dual imaging system.

Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.

The ovary is one of the first organs to exhibit signs of aging, characterized by reduced tissue function, chronic inflammation, and fibrosis. Multinucleated giant cells (MNGCs), formed by macrophage fusion, typically occur in chronic immune pathologies, including infectious and non-infectious granulomas and the foreign body response , but are also observed in the aging ovary . The function and consequence of ovarian MNGCs remain unknown as their biological activity is highly context-dependent, and their large size has limited their isolation and analysis through technologies such as single-cell RNA sequencing.