Publications by authors named "E A Kalinina"
Optogenetics is a combination of optical and genetic technologies used to activate or, conversely, inhibit specific cells in living tissues. The possibilities of using optogenetics approaches for the treatment of epilepsy, Parkinson's and Alzheimer's disease (AD) are being actively researched. In recent years, it has become clear that one of the most important players in the development of AD is astrocytes.
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- Older adults and those with chronic health conditions are particularly vulnerable to severe RSV disease, prompting research into the vaccine RSVpreF for high-risk individuals aged 18-59.
- In a phase 3 trial, participants received either RSVpreF or a placebo, with safety and immunogenicity monitored through various endpoints, revealing no serious adverse effects tied to the vaccine.
- Results showed that RSVpreF was well tolerated and met efficacy benchmarks, indicating it could be effectively used to prevent RSV-related illnesses in younger high-risk populations, similar to findings in older adults.
Objective: Atrial cardiomyopathy is closely associated with atrial fibrillation (AF), and some patients exhibit no dysfunction at rest but demonstrate evident changes in left atrial (LA) function and LA volume during exercise. This study aimed to identify distinguishing signs during exercise stress echocardiography (ESE) among patients in sinus rhythm (SR), with and without history of paroxysmal/persistent AF (PAF).
Methods: A prospective cohort of 1055 patients in SR was enrolled across 12 centers.
The most abundant tripeptide-glutathione (GSH)-and the major GSH-related enzymes-glutathione peroxidases (GPxs) and glutathione S-transferases (GSTs)-are highly significant in the regulation of tumor cell viability, initiation of tumor development, its progression, and drug resistance. The high level of GSH synthesis in different cancer types depends not only on the increasing expression of the key enzymes of the γ-glutamyl cycle but also on the changes in transport velocity of its precursor amino acids. The ability of GPxs to reduce hydroperoxides is used for cellular viability, and each member of the GPx family has a different mechanism of action and site for maintaining redox balance.
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- The article focuses on diagnosing and treating Buerger's disease, an uncommon inflammatory condition affecting small and medium blood vessels in limbs, which often poses a challenge for medical professionals.
- It presents a case of a 15-year-old girl who was misdiagnosed, initially believed to have suffered from complications related to a medical injection, leading to the amputation of her wrist due to dry gangrene.
- Through forensic histological studies and a thorough review of the patient’s medical records, the authors highlight how routine medical procedures can inadvertently trigger the onset of this rare disease and argue for better understanding and awareness in clinical practice.