CS/Au/MWCNT nanohybrid as an efficient carrier for the sustained release of 5-FU and a study of its cytotoxicity on MCF-7.

The chemical reduction method has been used to adeptly synthesize a CS/Au/MWCNT nanocomposite, to be used as a carrier for the effectual delivery of the anticancer drug 5-Fluorouracil. The work aims at utilizing the less investigated ternary nanocomposite system containing chitosan (CS), gold (Au) and MWCNT's to attain higher encapsulation efficiency and to enable a more sustained and prolonged release of 5-FU. This system has improved cytotoxicity when compared to the CS/Au binary system.

In vitro cytotoxicity study of dual drug loaded chitosan/palladium nanocomposite towards HT-29 cancer cells.

Conjugated drug delivery has gained immense interest due to the possibility of overcoming the resistance of cancer cells to a specific drug when treated using it for a period of time. In the present study, CS/Pd nanocomposite has been prepared using cost effective chemical reduction method and has been used for the delivery of curcumin (CUR) and 5-Fluorouracil (5-FU) separately and in a conjugated form. The prepared nanocomposite before and after drug encapsulation have been studied using various characterization techniques.

Synthesis and spectral characterization of silver embedded chitosan matrix nanocomposite for the selective colorimetric sensing of toxic mercury.

Polymer matrix type chitosan-silver nanocomposite containing different weight percentage of silver was synthesized by the chemical method. HRTEM images confirm the embedment of silver in the chitosan matrix. The binding of silver to the NH2 and OH groups of chitosan is evident from XPS and FTIR studies.