[The effect of the amine salt of 2,4-dichlorophenoxyacetic acid on the cluster- and colony-forming capacity of the bone marrow and on the mononuclear phagocyte system].

In experiments on 124 noninbred white rats weighing 180-200 g the influence of the intragastric administration of amino of 2,4-dichlorophenoxyacetic acid in doses of 2.0 and 20 mg/kg daily on the characteristics of their mononuclear phagocyte system was studied. The study revealed a decrease in the number of monocytic precursors in the marrow, an increase in their capacity for colony formation, the inhibited cell function on the periphery of the system simultaneously with the enhancement of oxidizing processes.

[An evaluation of the effect of 2,4-dichlorophenoxyacetic acid derivatives on humoral and cellular immunities].

A single oral administration of phenoxy herbicides, viz. 2,4-dichlorophenoxyacetic acid (2,4-D), amino salt, sodium salt, diethylene glycol, iso-octyl and octyl ethers in a dose of LD16, was found to produce a pronounced suppressive effect on humoral immunity on day 5. The 2,4-D derivatives under study, administered in the same dose, stimulated the manifestations of delayed-type hypersensitivity in mice immunized with sheep red blood cells.