[P-glycoprotein: structure, physiological role and molecular mechanisms of modulation functional activity].

In the review of literature the structure, localization and a physiological role of efflux biobiotics and xenobiotics transporter - P-glycoprotein - is characterized, molecular mechanisms of induction and inhibition of its functional activity are systematized.

[Sex differences of P-glycoprotein functional activity and expression in rabbits].

The research consists in the investigation of the sex differences of P-glycoprotein functional activity and expression in Chinchilla rabbits. P-glycoprotein functional activity was assessed by the pharmacokinetics of its probe substrate--fexofenadine after its single oral administration. P-glycoprotein expression was investigated by immunohistochemistry method.

[A comparative study of mexidol and mexiprim pharmacokinetic parameters].

Objective. To compare pharmacokinetic parameters of mexidol (coated tablets, "Farmasoft") and mexiprim (tablets film-coated, "STADA CIS"). Material and methods.

[The distribution of mexidol in the rat's brain and its subcellular fractions].

Objective: To study the penetration of mexidol through the blood-brain barrier into different brain compartments and cell mitochondria.

Material And Methods: The study was carried out on adult male Wistar rats using the drug mexidol ("Farmasoft" Russia). The penetration of mexidol into different compartments of the brain (the cortex, cerebellum, thalamus and medulla) and distribution between mitochondrial and cytoplasmic fractions of the cerebral cortex was studied.

[Local tissue hypoxia consequence in the trophic venous ulceration in elderly patients].

This paper analyzes the data of examination and the results of the treatment of 25 patients aged over 80 years (mean age 68.5+/-7 years) suffering from varicosity with long nonhealing trophic ulcers of the distal limb segments (CVI CMP C6) and 20 patients of the same age groups with CVI CEAP stages 3-5. All patients with CVI underwent either full-scope phlebectomy (64.