Publications by authors named "E A Haroun"
Article Synopsis
- Subaortic stenosis (SAS) is a condition in adults where a fibromuscular membrane obstructs blood flow below the aortic valve, potentially leading to serious heart complications.
- A study of 484 patients between 2011 and 2022 showed that over a median follow-up of 5.5 years, 11.5% died, and 6.8% were hospitalized for heart failure, with notable recurrence of SAS in 8.0% of cases.
- Key factors impacting mortality and disease recurrence included older age and baseline heart function, highlighting the need for more research to improve treatment strategies.
GBT1118, a Voxelotor Analog, Ameliorates Hepatopathy in Sickle Cell Disease.
Medicina (Kaunas)
September 2024
In sickle cell disease (SCD), hepatopathy is a cumulative consequence of ischemia/reperfusion (I/R) injury from a vaso-occlusive crisis, tissue inflammation, and iron overload due to blood transfusion. Hepatopathy is a major contributing factor of shortened life span in SCD patients. We hypothesized that the voxelotor, a hemoglobin allosteric modifier, ameliorates sickle hepatopathy.
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- Takotsubo cardiomyopathy (TC) is a serious heart condition often mistaken for a heart attack, occurring in about 1% of patients with acute coronary syndrome (ACS), primarily affecting older women.
- A study analyzed data from over 7 million ACS admissions from 2016 to 2020, highlighting factors linked to TC diagnosis and outcomes, particularly female sex and chronic heart failure.
- Researchers developed a new risk score that includes various health indicators to help predict in-hospital mortality for TC patients, but further validation is needed to ensure its effectiveness.