Publications by authors named "E A Hamber"
Background: Hemorrhagic shock is known to alter significantly the pharmacokinetics of fentanyl, an opioid that requires delivery to the liver for metabolism. The authors hypothesized that the pharmacokinetics and pharmacodynamics of remifentanil, an esterase metabolized opioid that does not require delivery to a metabolic organ, would be altered less by hemorrhagic shock that those of fentanyl.
Methods: Sixteen pigs were assigned randomly to control and shock groups.
Background: Intrathecal administration of morphine produces intense analgesia, but it depresses respiration, an effect that can be life-threatening. Whether intrathecal morphine affects the ventilatory response to hypoxia, however, is not known.
Methods: We randomly assigned 30 men to receive one of three study treatments in a double-blind fashion: intravenous morphine (0.
Study Objectives: To determine if there were any differences in the time to detect hypoxemia related to the site of peripheral pulse oximetry (ear, hand, and foot) during the rapid induction of hypoxemia in healthy volunteers.
Design: Repeated-measures, longitudinal, observational study.
Setting: Anesthesia clinical research area of the Department of Anesthesiology.
Intrathecal lipophilic opioids as adjuncts to surgical spinal anesthesia.
Reg Anesth Pain Med
July 1999
Background And Objectives: Lipophilic opioids, especially fentanyl and sufentanil, are increasingly being administered intrathecally as adjuncts to spinal anesthesia. This review analyzes the efficacy of these opioids for subarachnoid anesthesia.
Methods: Medline search of the literature from 1980 to the present and a survey of recent meeting abstracts are reviewed.