Endocrine organ metastases in subjects with lobular carcinoma of the breast.

Objective: To define the frequency and pattern of endocrine organ metastases in patients dying of invasive lobular carcinoma.

Design: Postmortem microscopic evaluation of the ovaries and adrenal, pituitary, thyroid, and parathyroid glands for breast cancer metastases.

Setting: Roswell Park Cancer Institute, Buffalo, NY, between 1971 and 1990.

Results of salvage mastectomy for local recurrence after breast-conserving surgery without radiation therapy.

Background: Between 1975 and 1987, 128 patients with infiltrating breast cancer, categorized as clinical Stage I and II disease, were treated by breast conservation surgery without radiation therapy.

Materials: After a median disease-free interval of 20 months (range, 8-64 months), 25 of 128 patients had local recurrence, for which salvage mastectomy was performed. The results of modified radial mastectomy as a salvage procedure were analyzed in these 25 patients.

Survival of patients with stage B2 colon carcinoma. The Gastrointestinal Tumor Study Group experience.

The Gastrointestinal Tumor Study Group, a multispecialty collaborative clinical research program, executed two studies of surgically resected colon carcinoma, including patients with serosal penetration but no positive regional lymph nodes (stage B2). In the first study, 232 patients with stage B2 disease were operated on and survival was unaffected by therapy. In the stage B2 group, survival was 78% at five years, and is estimated to be 64% ten years after surgery.

Intraoperative photodynamic therapy for retroperitoneal sarcomas.

A pilot study was done to determine the feasibility of adjuvant photodynamic therapy (PDT) in recurrent retroperitoneal sarcomas. Ten patients, who had recurrences after conventional methods of treatment, had repeated resections of the tumor and intraoperative photodynamic treatment to the tumor bed. The methods and equipment used are detailed.