Publications by authors named "E A Grana"
Article Synopsis
- Musculoskeletal disorders (MSDs) are a big problem for people who work in offices, causing pain and health issues.
- A program was tested in Greece from 2019 to 2022 to help workers learn about better work habits and exercises to reduce these problems.
- The results showed that those who participated early had less presenteeism (working while not fully healthy), less pain in several body parts, and improved health, while those who participated later didn’t see much change.
Incidence and clinical progression of asymptomatic peripherally inserted central catheterrelated thrombosis in solid neoplasm patients: ultrasound insights from a prospective cohort study.
Res Pract Thromb Haemost
March 2024
Article Synopsis
- This study focuses on the challenges of managing central venous catheters in cancer patients, particularly with peripherally inserted central catheter (PICC) systems, and evaluates the role of ultrasound in detecting catheter-related thrombosis (CRT).
- Among 120 cancer patients undergoing chemotherapy, 25.8% experienced CRT, most cases occurring within 30 days and often asymptomatic; traditional PICCs were linked to a higher risk compared to PICC-PORTs.
- Findings indicate that ultrasound monitoring is effective for identifying asymptomatic CRT in patients with solid tumors, especially those with a high risk of thrombosis, highlighting the need for larger studies to explore treatment options for these cases. *
Introduction: -cinnamaldehyde is a specialised metabolite that naturally occurs in plants of the Lauraceae family. This study focused on the phytotoxic effects of this compound on the morphology and metabolism of seedlings.
Material And Methods: To evaluate the phytotoxicity of -cinnamaldehyde, a dose-response curve was first performed for the root growth process in order to calculate the reference inhibitory concentrations IC50 and IC80 (-cinnamaldehyde concentrations inducing a 50% and 80% inhibition, respectively).
The sesquiterpene farnesene and the monoterpene citral are phytotoxic natural compounds characterized by a high similarity in macroscopic effects, suggesting an equal or similar mechanism of action when assayed at IC concentration. In the present study, a short-time experiment (24 and 48 h) using an imaging spectrofluorometer allowed us to monitor the in-vivo effects of the two molecules, highlighting that both terpenoids were similarly affecting all PSII parameters, even when the effects of citral were quicker in appearing than those of farnesene. The multivariate, univariate, and pathway analyses, carried out on untargeted-metabolomic data, confirmed a clear separation of the plant metabolome in response to the two treatments, whereas similarity in the affected pathways was observed.
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