[Altered renal function in acute sodium nitrite intoxication experiment].

In experiments on non-inbred albino rats, intoxication was reproduced with 1% aqueous sodium nitrite solution, which was rated by the degree of hemic hypoxia (HH). The findings suggest that changes in renal functions (osmo-regulating, sodium-regulating) occur due to the development of mild HH, by increasing as hypoxia deteriorates. Decreased glomerular filtration and proteinuria, which are concomitantly detected, point to their mixed glomerulotubular pattern of renal lesion in nitrite intoxication.

[Method to determine nitrite and nitrate ecologic load on humans].

To evaluate ecologic load with nitrite-nitrate ions, the authors suggest determining the diurnal excretion and then excluding contribution of the endogenous compounds.