Publications by authors named "E A Goodall"

Good relationships between families and schools make a difference to children's learning - and the same goes for autistic children. But parents of autistic children often find it very stressful interacting with teachers and school staff. In this study, we focused on autistic parents of autistic children.

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is a globally disseminated pathogen that is the cause of over 100 million infections per year. The resulting diseases are dependent upon host susceptibility and the infecting serovar. As serovar Typhimurium induces a typhoid-like disease in mice, this model has been used extensively to illuminate various aspects of infection and host responses.

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Article Synopsis
  • * Researchers conducted a genome-wide screen on ECL8, an endemic bacterial strain, to identify essential genes for growth in various environments, including laboratory media and human bodily fluids.
  • * They discovered 427 essential genes for growth in lab conditions, along with additional genes critical for survival in human urine and serum, highlighting potential new antimicrobial targets for treating these infections.
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There is a lack of new antibiotics to combat drug-resistant bacterial infections that increasingly threaten global health. The current pipeline of clinical-stage antimicrobials is primarily populated by "new and improved" versions of existing antibiotic classes, supplemented by several novel chemical scaffolds that act on traditional targets. The lack of fresh chemotypes acting on previously unexploited targets (the "holy grail" for new antimicrobials due to their scarcity) is particularly unfortunate as these offer the greatest opportunity for innovative breakthroughs to overcome existing resistance.

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