Publications by authors named "E A Golub"
Frequent Cocaine Use is Associated With Larger HIV Latent Reservoir Size.
J Acquir Immune Defic Syndr
October 2024
Article Synopsis
- Cocaine is a commonly abused drug among people living with HIV, negatively affecting their health by slowing down the decline of viral production after starting antiretroviral therapy and leading to higher viral loads and faster disease progression.
- The study focused on 434 women with varying ancestry participating in a national cohort study, analyzing the impact of cocaine use on the HIV latent reservoir in their CD4+ T-cells.
- Results showed that current and prior cocaine users have significantly larger HIV latent reservoir sizes compared to non-users, highlighting the need for more research on cocaine's effects on women's HIV outcomes.
Giant exoplanets orbiting close to their host stars are unlikely to have formed in their present configurations. These 'hot Jupiter' planets are instead thought to have migrated inward from beyond the ice line and several viable migration channels have been proposed, including eccentricity excitation through angular-momentum exchange with a third body followed by tidally driven orbital circularization. The discovery of the extremely eccentric (e = 0.
View Article and Find Full Text PDFThe microperoxidase-11 hemopeptide exhibits configuration-dependent selectivity for guanine-quadruplexes by specifically uncaging c-MYC guanine-quadruplexes from a duplex DNA.
View Article and Find Full Text PDFArticle Synopsis
- Novel monoclonal antibodies (MAbs) need to effectively neutralize various sarbecoviruses and adapt to new variants of SARS-CoV-2, with a focus on the class V epitope for broader protection.
- The crystal structure of the SARS-CoV-2 receptor binding domain (RBD) in complex with the MAb WRAIR-2063 reveals its ability to target a conserved region, effectively binding to multiple variants and highlighting its potential as a universal therapeutic option.
- This research on MAbs from vaccination or natural infection provides important insights into their role in combating COVID-19, suggesting the class V epitope could be a key target for developing future vaccines and therapies against related viruses.
Article Synopsis
- The study investigates how changes in gut microbiota are linked to inflammation and metabolite profiles in relation to atherosclerosis, particularly in women with or at risk of HIV.
- Researchers found that the bacteria Fusobacterium nucleatum is linked to increased carotid artery plaque, while five other species were inversely related to plaque presence.
- Furthermore, certain inflammatory markers in the serum were associated with these microbial species, suggesting a complex interplay between gut bacteria, inflammation, and cardiovascular health in the context of HIV.