Publications by authors named "E A Goldman"
Because of the urgent need for new antibiotics to treat drug-resistant bacterial pathogens, we employed an assay that rapidly screens large quantities of compounds for their ability to interfere with bacterial protein synthesis, in particular, the delivery of amino acids to the ribosome via tRNA and elongation factor Tu (EF-Tu). We have identified a drug lead, named MGC-10, which kills Gram-positive bacteria, including methicillin-resistant (MRSA), with a MIC of 6 µM, while being harmless to mammalian cells in that concentration range. The antibacterial activity of MGC-10 was broad against over 50 strains of antibiotic-resistant samples obtained from hospital infections, where MGC-10 inhibited all tested strains of MRSA.
View Article and Find Full Text PDFBackground: Nystagmus in infancy may occur as part of an ocular condition, a neurological disorder or be idiopathic. The objective of our study was to evaluate the main causes for nystagmus in infants aged 0-1 year, the accompanying clinical characteristics and the effectiveness of different diagnostic tests used for reaching definite diagnosis.
Methods: A retrospective study was conducted on medical records of infants who were seen at a tertiary hospital between 2016 and 2021.
Article Synopsis
- The study investigates how genetic variations that influence gene regulation, specifically through DNA methylation, contribute to differences in traits among rhesus macaques on Cayo Santiago Island, Puerto Rico.
- Researchers utilized bisulfite sequencing to assess DNA methylation at over 555,000 CpG sites across 573 macaque blood samples, discovering significant genetic effects on methylation levels from single nucleotide polymorphisms (SNPs).
- Findings revealed that 69.12% of the investigated CpGs had a genetic influence on their methylation (meQTL), which were predominantly located in regions associated with gene expression, highlighting genetic factors that drive phenotypic diversity in these primates.
Article Synopsis
- The study explores the origins of timber species to determine if they come from natural forests or less regulated planted forests to evaluate the legality of global wood products.
- A new dataset, called Planted Forest Timber Data, was created, combining 'polygon' data from the World Resources Institute and 'non-polygon' data from research and government sources, covering multiple countries and species.
- This dataset aims to support global leaders in forest governance and policy-making, promoting legal timber trade and protecting biodiversity as it continues to expand and improve.
A lack of trained faculty is a frequently reported barrier to integrating ultrasound training into medical education. Clinical anatomy faculty are a promising pool from which to recruit and train new ultrasound educators. To date, there are no studies related to best practices for training anatomists in ultrasound skills and preparing them to teach the next generation of health care providers this crucial clinical skill.
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