A Lock-and-Kill Anticancer Photoactivated Chemotherapy Agent.

Photosubstitutionally active ruthenium complexes show high potential as prodrugs for the photoactivated chemotherapy (PACT) treatment of tumors. One of the problems in PACT is that the localization of the ruthenium compound is hard to trace. Here, a ruthenium PACT prodrug, [Ru(3)(biq)(STF-31)](PF ) (where 3 = 3-(([2,2':6',2″-ter- pyridin]-4'-yloxy)propyl-4-(pyren-1-yl)butanoate) and biq = 2,2'-biquinoline), has been prepared, in which a pyrene tracker is attached via an ester bond.

Environmental Variables Influencing Five Speyeria (Lepidoptera: Nymphalidae) Species' Potential Distributions of Suitable Habitat in the Eastern United States.

Five closely related species of greater fritillaries occur in North America east of the Mississippi River: regal fritillary (Speyeria idalia Drury [Lepidoptera: Nymphalidae]), Diana fritillary (Speyeria diana Cramer [Lepidoptera: Nymphalidae]), great spangled fritillary (Speyeria cybele Fabricius [Lepidoptera: Nymphalidae]), Atlantis fritillary (Speyeria atlantis Edwards [Lepidoptera: Nymphalidae]), and Aphrodite fritillary (Speyeria aphrodite Fabricius [Lepidoptera: Nymphalidae]). The regal fritillary and Diana fritillary are species of concern, whereas the great spangled fritillary, Atlantis fritillary, and Aphrodite fritillary are relatively abundant within their respective ranges. However, the Atlantis fritillary and Aphrodite fritillary have experienced severe population declines within the last few decades.

Contactless Spin Switch Sensing by Chemo-Electric Gating of Graphene.

Direct electrical probing of molecular materials is often impaired by their insulating nature. Here, graphene is interfaced with single crystals of a molecular spin crossover complex, [Fe(bapbpy)(NCS) ], to electrically detect phase transitions in the molecular crystal through the variation of graphene resistance. Contactless sensing is achieved by separating the crystal from graphene with an insulating polymer spacer.

Sensing at the Surface of Graphene Field-Effect Transistors.

Recent research trends now offer new opportunities for developing the next generations of label-free biochemical sensors using graphene and other two-dimensional materials. While the physics of graphene transistors operated in electrolyte is well grounded, important chemical challenges still remain to be addressed, namely the impact of the chemical functionalizations of graphene on the key electrical parameters and the sensing performances. In fact, graphene - at least ideal graphene - is highly chemically inert.

Multiple lineages of Avian malaria parasites (Plasmodium) in the Galapagos Islands and evidence for arrival via migratory birds.

Haemosporidian parasites in the genus Plasmodium were recently detected through molecular screening in the Galapagos Penguin (Spheniscus mendiculus). We summarized results of an archipelago-wide screen of 3726 endemic birds representing 22 species for Plasmodium spp. through a combination of molecular and microscopy techniques.