Publications by authors named "E A G Joosten"
Article Synopsis
- Long-term conventional spinal cord stimulation (LT-SCS) is effective for treating painful diabetic peripheral neuropathy (PDPN) initially, but its effectiveness may decline over time.
- *In a rat study, LT-SCS led to increased thresholds for mechanical hypersensitivity and changes in nerve fiber density, indicating structural adaptations in response to pain.
- *The study suggests that LT-SCS reduces certain proteins associated with pain pathways, revealing potential mechanisms for its effectiveness in managing PDPN symptoms.*
Background: While the incidence of neonatal intensive care unit (NICU) admission steadily increases, neonatology lacks evidence of a safe, effective, and preventive analgesic for treating procedural pain. Given its role in nociception and promoting healthy neurodevelopment, the endogenous neuropeptide oxytocin (OT) emerges as a promising candidate.
Methods: This study investigates the use of daily repeated subcutaneous OT (1 mg/kg) treatment in an established model of neonatal repetitive procedural pain and assesses the effectivity of OT treatment on mechanical sensitivity and body weight.
Objectives: Diabetes-induced peripheral nerve fiber damage can cause painful diabetic polyneuropathy (PDPN), induced by central sensitization through proinflammatory processes in the spinal dorsal horn. Disturbances in spinal dorsal horn lipid metabolism play a major role in proinflammatory regulation. Conventional (Con)-spinal cord stimulation (SCS) is an alternative treatment for pain relief in PDPN, whereas differential target multiplexed (DTM)-SCS could be more effective than Con-SCS, specifically targeting the spinal inflammatory response.
View Article and Find Full Text PDFObjectives: Spinal cord stimulation (SCS) is an alternative treatment option for painful diabetic polyneuropathy (PDPN). Differential target multiplexed (DTM)-SCS is proposed to be more effective than conventional (Con)-SCS. Animal studies are essential for understanding SCS mechanisms in PDPN pain relief.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the genetic factors contributing to chronic post-surgical pain (CPSP) by analyzing data from 1,350 individuals who underwent various types of surgery, and highlights a significant genetic component, estimating a 39% heritability for CPSP through meta-analysis.
- - Researchers identified 77 key genetic variations (SNPs) linked to CPSP and noted that most of these are associated with immune system genes, especially those related to B and T cells.
- - Animal studies showed that mice without T and B cells experienced worsened pain after surgery, which could be mitigated by transferring B cells, suggesting that the adaptive immune system plays a crucial protective role against CPSP.