Publications by authors named "E A Fong"
Article Synopsis
- * The research explored how the shape and confinement of CAFs on specially designed surfaces influence their morphology and gene expression, finding that certain conditions led to changes toward more inflammatory and desmoplastic CAF types.
- * The findings suggest that the way CAFs are physically arranged affects their response to cancer therapies, suggesting that understanding CAF plasticity can help develop better treatment strategies.
Introduction: Chronic kidney disease (CKD) demonstrates a complex interaction with tobacco exposure and sex differences, where females and males may experience varying risks and outcomes. This study aims to investigate how sex differences mediate the relationship between tobacco exposure and CKD development, with a secondary focus on regional variability and social determinants of health.
Study Selection And Criteria: Comprehensive searches on MEDLINE, EMBASE, clinicaltrials.
In aging, skeletal muscle regeneration declines due to alterations in both myogenic and non-myogenic cells and their interactions. This regenerative dysfunction is not understood comprehensively or with high spatiotemporal resolution. We collected an integrated atlas of 273,923 single-cell transcriptomes and high-resolution spatial transcriptomic maps from muscles of young, old and geriatric mice (~5, 20 and 26 months old) at multiple time points following myotoxin injury.
View Article and Find Full Text PDFGrowing evidence points to the tumor microenvironment's role in developing drug resistance. A key element of this microenvironment is inter-cellular communication, which includes the release of membrane-encapsulated vesicles containing various cargo, known as extracellular vesicles (EVs). Understanding how EVs contribute to acquired resistance holds significant clinical implications.
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