Publications by authors named "E A Fedotova"

In this report, we developed novel chlorin/arylaminoquinazoline conjugates for targeted photodynamic therapy of cancer. The synthesized photosensitizers consisted of chlorin- metallocomplexes (Zn, In, or Pd) conjugated with arylaminoquinazoline ligands with high affinity for epidermal growth factor receptors (EGFR). Additionally, the selectivity and antitumor properties of the conjugates were investigated in the EGFR-expressing A431 human tumor cell line .

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Introduction: Non-fluent variant of primary progressive aphasia (nfvPPA) is a neurodegenerative disorder with a predominantly speech and language impairment. Apraxia of speech and expressive agrammatisms along with decreased speech fluency and impaired grammar comprehension are the most typical disorder manifestations but with the course of the disease other language disturbances may also arise. Most studies have investigated these symptoms individually, and there is still no consensus on whether they have similar or different neuroanatomical foundations in nfvPPA.

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Parkinson's disease (PD) is one of the most common progressive neurodegenerative diseases. An important feature of the disease is its long latent period, which necessitates search for prognostic biomarkers. One method of identifying biomarkers of PD is to study changes in gene expression in peripheral blood of the patients in early stages of the disease and have not been treated.

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Parkinson's disease (PD) is one of the most common human neurodegenerative diseases. Belated diagnoses of PD and late treatment are caused by its elongated prodromal phase. Thus, searching for new candidate genes participating in the development of the pathological process in the early stages of the disease in patients who have not yet received therapy is relevant.

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Article Synopsis
  • The article focuses on diagnosing and treating Buerger's disease, an uncommon inflammatory condition affecting small and medium blood vessels in limbs, which often poses a challenge for medical professionals.
  • It presents a case of a 15-year-old girl who was misdiagnosed, initially believed to have suffered from complications related to a medical injection, leading to the amputation of her wrist due to dry gangrene.
  • Through forensic histological studies and a thorough review of the patient’s medical records, the authors highlight how routine medical procedures can inadvertently trigger the onset of this rare disease and argue for better understanding and awareness in clinical practice.
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