The effects of benoxaprofen on mononuclear and polymorphonuclear leucocyte motility. An in vitro and in vivo study.

Benoxaprofen at concentrations well within the normal therapeutic range was found to cause significant inhibition of both mononuclear leucocyte (MNL) and polymorphonuclear leucocyte (PMNL) motility in vitro. The ingestion of benoxaprofen 600 mg also resulted in a significant reduction of MNL migration, while co-incubation of control PMNLs with 25% heat-inactivated serum from healthy subjects resulted in a very significant inhibition of PMNL motility. Serum IgG levels also dropped significantly after benoxaprofen ingestion.