Publications by authors named "E A Dorsey"
In a prospective, remote natural history study of 277 individuals with (60) and genetically at risk for (217) Parkinson's disease (PD), we examined interest in the return of individual research results (IRRs) and compared characteristics of those who opted for versus against the return of IRRs. Most ( = 180, 65%) requested sharing of IRRs with either a primary care provider, neurologist, or themselves. Among individuals without PD, those who requested sharing of IRRs with a clinician reported more motor symptoms than those who did not request any sharing (mean (SD) 2.
View Article and Find Full Text PDFBackground And Objectives: To identify trends in educational debt for US medical school graduates entering neurology and compare debt to anticipated compensation.
Methods: Data of 148 accredited medical schools were obtained from the Association of American Medical Colleges Graduation and Matriculating Student Questionnaires to identify self-reported educational debt for graduates pursuing neurology training. Trends were assessed in a 2-year interval from 2010 to 2021.
Article Synopsis
- - Huntington's disease (HD) impacts both upper and lower limb function, and this study used a wrist-worn sensor to monitor upper limb movements in daily activities among individuals with HD, prodromal HD (pHD), and healthy controls (CTR) over a week.
- - Participants were highly compliant in wearing the sensor, and the study analyzed goal-directed movements (GDM) using deep learning, finding significant differences in GDM characteristics among the three groups, particularly noting that HD individuals performed fewer long-duration movements compared to CTR.
- - The research successfully used statistical and machine learning models to distinguish between the groups and predict clinical scores, achieving a balanced accuracy of 67%, with certain movement metrics correlating strongly with clinical evaluations
Digital measures may provide objective, sensitive, real-world measures of disease progression in Parkinson's disease (PD). However, multicenter longitudinal assessments of such measures are few. We recently demonstrated that baseline assessments of gait, tremor, finger tapping, and speech from a commercially available smartwatch, smartphone, and research-grade wearable sensors differed significantly between 82 individuals with early, untreated PD and 50 age-matched controls.
View Article and Find Full Text PDFThe brain- and body-first models of Lewy body disorders predict that aggregated alpha-synuclein pathology usually begins in either the olfactory system or the enteric nervous system. In both scenarios the pathology seems to arise in structures that are closely connected to the outside world. Environmental toxicants, including certain pesticides, industrial chemicals, and air pollution are therefore plausible trigger mechanisms for Parkinson's disease and dementia with Lewy bodies.
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