Publications by authors named "E A Dobreva"
Article Synopsis
- Acquired 16S rRNA methyltransferases (16S-RMTases) enable high resistance to aminoglycosides and are linked to resistance against other antibiotics like β-lactams and quinolones.
- A study conducted on over 10,000 bacterial isolates from 2006 to 2023 found that 1.4% of them carried various methyltransferase genes alongside other significant resistance genes.
- The research highlighted the diverse origins of these resistance genes in different plasmids and indicated that their ability to acquire more resistance genes poses a significant long-term public health risk.
Article Synopsis
- Carbapenemase-producing Enterobacteriaceae, specifically the ESCPM group, are increasingly recognized as major causes of hospital-acquired infections but lack systematic genomic tracking.
- A study analyzed 36 clinical isolates from Bulgaria, identifying various carbapenemase genes, with NDM-1 and VIM-4 being the most common.
- The majority of these resistance genes were found on self-conjugative plasmids, indicating a high potential for gene transfer and reinforcing the need for better infection control protocols.
Introduction: Cardiovascular diseases (CVD) and metabolic disorders (MD) have retained leading positions in the structure of morbidity and mortality for many years. Primary hyperparathyroidism (PHPT) is also associated with a greater incidence of CVD and MD. The aim of the present study was to describe the prevalence and structure of CVD and MD in hospitalized patients with PHPT and to search for possible associations between these pathologies.
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- Multidrug-resistant infections are a significant public health issue, emphasizing the need to understand their genetic characteristics.
- This study discovered the first case of imipenemase (IMP)-carrying strains in Bulgaria, identifying a novel IMP-100 allele and other chromosomal IMP variants.
- The study finds that these bacterial strains are resistant to last-resort antibiotics but maintain susceptibility to colistin, with various virulence factors indicating a high potential for pathogenicity and biofilm formation.
- The emergence of IMP-producing strains is concerning, especially as they show resistance to advanced antibiotics like cefiderocol (CFDC).
Introduction: Until recently no major epidemiological research of primary hyperparathyroidism (PHPT) has been conducted in the Russian Federation, this led to the creation of the Russian online registry. The objective of this study is to estimate the clinical and biochemical profile, classical and non-classical complications, surgical intervention and medical therapy of the patients with different forms of PHPT in the Russian Federation.
Materials And Methods: The cross-sectional, observational, continuous study was conducted at the Endocrinology Research Centre (Moscow).