[The use of L-lysine aescinat in the treatment of microcirculatory disturbances in patients young and middle age with violation of the intracranial venous outflow].

Aim: To study the efficacy of L-lysine aescinat in the treatment of vascular and microvascular disorders in patients with cerebral venous dystonia.

Material And Methods: Sixty-eight patients, 25 male and 43 female, aged from 25 to 56 years, with disturbances of venous cerebral blood circulation and venous outflow difficulties were examined. The examination included the assessment of cerebral hemodynamics using the algorithm of complex ultrasound examinations and functional status of the microcirculation by the laser Doppler flowmetry (LDF) at baseline and 10 days after treatment with L-lysine aescinat.

[The classification and topical diagnosis of cerebral circulatory disorders in newborn infants].

The classification of disorders of cerebral circulation (DCC) was presented on the basis of clinical-neurosonic study of 100 newborn children with the signs of DCC. There were-determined the same degrees of DCC severity as in hypoxic-ischemic encephalopathy (that is light, manifested, severe ones). There weren't observed any signs of focal damages of brain in light form of DCC, although there might sometimes be found the small ischemic damages of brain and injuries of hemorrhagic type in one third of patients.

[Density of lymphocyte beta-2 adrenoreceptors in the course of hypertension].

Baseline density of intact lymphocyte beta2 adrenoreceptors (B max., 3H-DHA) was compared to dynamics of left ventricular hypertrophy (LVH) and frequency of essential hypertension (EH) complications within 7-9-year follow-up in 27 patients with EH stage II. No significant correlation was noted between B max and LVH changes.

[The effect of obzidan monotherapy on the beta 2-adrenoreceptors of the lymphocyte adenylate cyclase system in hypertension patients].

Obsidan (propranolol) monotherapy was investigated for the effect on the density of lymphocytic beta2-adrenoreceptors (B max), the activity of lymphocytic homogenates adenylate cyclase (AC), plasma renin activity (PRA), aldosterone concentration (A) and plasma catecholamines (CA). Obsidan treatment brought about a 40% increase in B max without a significant changes in AC activity. Contrary to a significant fall in PRA, A and norepinephrine in plasma reduced insignificantly.