Pubertal stage significantly and independently impacts C-peptide levels at type 1 diabetes diagnosis along with body mass index and age.

Unlabelled: Assessment of beta-cell function in type 1 diabetes (T1D) has important implications in both clinical and research settings. Studies demonstrating the extent to which puberty influences C-peptide levels are scarce. The aim of this study was to evaluate the influence of pubertal stage, along with age and body mass index (BMI), on multiple C-peptide measures at T1D diagnosis.

A Little Known but Very Common Phenotype in Patients with Severe Congenital Neutropenia due to HAX1 Deficiency: Premature Ovarian Insufficiency.

Background: Autosomal recessive severe congenital neutropenia (SCN) has been associated with homozygous variants in the HAX1 gene. The aim of this cross-sectional study was to evaluate the gonadal function and pubertal development in pediatric patients with SCN due to HAX1 gene variant (HAX1-SCN).

Methods: Forty-five patients, including 24 females (median age 11.

Extremely rare cause of hyperkalemia: ileostomy‒induced hyperkalemia in extremely low birth weight infants.

Background: Hyperkalemia is one of the most serious electrolyte disturbances, and it can cause lethal cardiac arrhythmia. Although hyperkalemia associated with ileostomies has been reported in adults, to the best of our knowledge, it has not previously been reported in neonates.

Case: We report ileostomy‒induced hyperkalemia that persisted during the ileostomy and resolved promptly after the closure of the ileostomy in two extremely low birth weight (ELBW) infants, with birth weights of 850 g and 840 g and gestational ages of 27 weeks and 27 weeks 6 days.

Online health information on thyroid nodules: do patients understand them?

Background: Given the lack of a previous study assessing understandability and considering there is only one study assessing the readability and quality of online information related to thyroid nodules, we aimed to assess the readability, understandability, and quality of online patient education materials on thyroid nodules.

Methods: Materials were identified through an online search performed by inputting the term "thyroid nodule" into Google. A total of 150 websites were identified, 59 met the inclusion criteria.