[Sepsis-induced immune paralysis: pathogenesis, diagnosis, and possible modes of correction].

Recent clinical and experimental studies indicate that the pathogenesis of a septic process in critically ill patients may be divided into two stages: (1) a systemic inflammatory reaction and (2) immune paralysis. Verification of biological markers of both stages is the key point for choosing adequate drug therapy. Immune paralysis virtually shows no clinical symptoms, at the same time this condition can be diagnosed at the earliest stages, by applying a number of laboratory techniques.

[Etiology of postoperative bacteremias in an intensive care unit: an association with the level of procalcitonin].

The etiology of bacteremia determines the choice of adequate therapy for severe infections. The clinical manifestations of gram-negative and gram-positive bacterial infections are similar while biological markers may serve as a guide for the early diagnosis of the nature of a pathogen. The paper analyzes data on the rate and etiology of bacteremia in 1360 patients at the A.