Effect of adenosine and pertussis vaccine on lymphocyte response in vitro to phytohemagglutinin in asthmatic and non-asthmatic subjects.

Adenosine and pertussis vaccine each significantly suppressed the in vitro lymphocyte response to phytohemagglutinin (PHA) in both asthmatic and non-asthmatic subjects. On the other hand, pertussis vaccine significantly enhanced the response of the lymphocytes treated with a lower concentration of adenosine both in asthmatic and non-asthmatic subjects. It was also shown that lymphocytes from asthmatic and non-asthmatic subjects responded similarly to the modulating effect of adenosine and/or pertussis vaccine on PHA stimulation.

Effects of common analgesics on the in vitro suppression of lymphocyte mitogen responses by cephalosporins.

Acetaminophen and indomethacin either did not alter or partially reversed the inhibition of lymphocyte mitogenic responses by cephalosporins. Aspirin at concentrations of >/=100 mug/ml in cultures containing cephalosporins reduced the response below the level with either drug alone.